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张起辉,教授/博士生导师。2010年毕业于药学专业学府“沈阳药科大学”,师从著名天然药物学家裴月湖教授和吴立军教授;曾在世界十大名校之一的美国芝加哥大学进行访学,师从国际著名药学家Yuan Cunsu教授。2010年至今,就职于太阳成集团。 作为项目负责人主持和主研国家级项目5项,主持和主研省部级项目7项,主持和主研企业横向课题多项,发表SCI论文数十篇,获专利十余项。 曾获重庆市青年教师讲课比赛二等奖;太阳成集团青年教师讲课比赛一等奖;tyc1286太阳集团讲课比赛一等奖;太阳成集团总工会表彰;太阳成集团最受员工欢迎十佳教师;太阳成集团教学工作优秀教师;太阳成集团优秀青年教师;太阳成集团先进工作者;唐立新奖教金获得者;爱以森优秀教师奖教金获得者。 |
联系方式
E-mail:qhzhang@cqu.edu.cn Tel:15123116558
研究方向
应用新材料开拓中药研究新方法:基于分子印迹材料和各种新材料,以及固相萃取及微萃取等新技术,开拓中药组分研究新方法,拓展中药研究新领域。
天然产物提取分离与结构修饰:基于重庆道地药材,研究其中主要的化学成分,建立新颖的筛选体系,在类型繁多的化合物中找到具有开发前景的化合物,根据构效关系进一步进行结构修饰,希望使其发挥更大的药效。
天然产物的应用研究:在找到具有开发前景的化学物质的基础上,进一步根据化合物的理化性质和治疗方向确定工艺和剂型,为药物的临床开发或保健品开发奠定物质基础。
代表性论文、专著和专利
近年代表作:
1) Zhang Qi-Hui*, Zhou Lian-Di, Chen Hua, Wang Chong-Zhi, Xia Zhi-Ning*, Yuan Chun-Su. Solid-phase microextraction technology for in vitro and in vivo metabolite analysis. TRAC-TREND ANAL CHEM, 2016, 80: 57-65. (IF=13.1, Q1)
2) Jia-Yuan He, Qin Li, Hui-Xian Xu, Qin-Yue Zheng, Qi-Hui Zhang*, Lian-Di Zhou, Chong-Zhi Wang, Chun-Su Yuan. Recognition and analysis of biomarkers in tumor microenvironments based on promising molecular imprinting strategies with high selectivity. TRAC-TREND ANAL CHEM, 2023, 162: 117033. (IF=13.1, Q1)
3) Hu-Xian Xu, Yan-Jun Li, Qin Li, Dan-Dan Yang, Ting Li, Sai-Meng Jin, Lian-Di Zhou, Qi-Hui Zhang*, James H. Clark. Reactive oxygen species induced by plant essential oil for effective degradation of p-phenylenediamine. GREEN CHEM, 2023, 25(14): 5647-5653. (IF=11.0, Q1)
4) Yan-Jun Li, Li-Li Yang, Li Ni, Jia-Min Xiong, Jia-Yuan He, Lian-Di Zhou, Ling Luo, Qi-Hui Zhang*, Chun-Su Yuan. Constructing electrochemical sensor using molecular-imprinted polysaccharide for rapid identification and determination of l-tryptophan in diet. FOOD CHEM, 2023, 425: 136486. (IF=8.8, Q1)
5) Shu-Xian Wang, Rong-Rong Ma, Ying Z. Mazzu, Jia-Wei Zhang, Wei Li, Ling Tan, Lian-Di Zhou*, Zhi-Ning Xia, Qi-Hui Zhang*, Chun-Su Yuan. Specific adsorption of tetracycline from milk by using biocompatible magnetic molecular imprinting material and evaluation by ECD. FOOD CHEM, 2020, 326: 126969. (IF=8.8, Q1)
6) Jia-Yuan He, Qing-Yao Li, Li-Li Yang, Rong-Rong M, Chong-Zhi Wang, Lian-Di Zhou, Qi-Hui Zhang*, Zhi-Ning Xia, Chun-Su Yuan. Synergistic recognition of transferrin by using performance dual epitope imprinted polymers. ANAL CHIM ACTA, 2021, 1186: 339117. (IF=6.2, Q1)
7) Jia-Wei Zhang, Jia-Yuan He, Chong-Zhi Wang, Feng-Qing Yang, Lian-Di Zhou, Qi-Hui Zhang*, Zhi-Ning Xia, Chun-Su Yuan. Simultaneous extraction of several targets by using non-toxic dual template molecularly imprinted polymers in vivo and in vitro. Talanta, 2020, 219: 121283. (IF=6.1, Q1)
8) Jia-Wei Zhang, Ling Tan, Jin-Bin Yuan, Ri-Fa Qiao, Chong-Zhi Wang, Feng-Qing Yang, Lian-Di Zhou, Qi-Hui Zhang*, Zhi-Ning Xia, Chun-Su Yuan. Extraction of activated epimedium glycosides in vivo and in vitro by using bifunctional-monomer chitosan magnetic molecularly imprinted polymers and identification by UPLC-Q-TOF-MS. Talanta, 2020, 219, 121350. (IF=6.1, Q1)
9) Zong-Liang Sun, Yu-Zhen Zhang, Zhang Feng, Jia-Wei Zhang, Guo-Can Zheng, Ling Tan, Chong-Zhi Wang, Lian-Di Zhou, Qi-Hui Zhang*, Chun-Su Yuan. Quality assessment of Penthorum chinense Pursh through multicomponent qualification and fingerprint, chemometric, and antihepatocarcinoma analyses. FOOD FUNCT, 2018, 9 (7): 3807-3814. (IF=6.1, Q1)
10) Yu-Zhen Zhang, Jia-Wei Zhang, Chong-Zhi Wang, Lian-Di Zhou, Qi-Hui Zhang*. Polydopamine-Coated Magnetic Molecularly Imprinted Polymers with Fragment Template for Identification of Pulsatilla Saponin Metabolites in Rat Feces with UPLC-Q-TOF-MS. J AGR FOOD CHEM, 2018, 66: 653-660. (IF=6.1, Q1)
11) Die Gao, Dan-Dan Wang, Qian Zhang, Feng-Qing Yang, Zhi-Ning Xia*, Qi-Hui Zhang *, Chun-Su Yuan. In Vivo Selective Capture and Rapid Identification of Luteolin and Its Metabolites in Rat Livers by Molecularly Imprinted Solid-Phase Microextraction. J AGR FOOD CHEM, 2017, 65(6): 1158-1166. (IF=6.1, Q1)
12) Jia-Yuan He, Hui-Xian Xu, Qin Li, Qin-Yue Zheng, Qin-Yue Zheng, Lian-Di Zhou, Ling Luo, Qi-Hui Zhang*, Chun-Su Yuan. Specific capture and determination of glycoprotein using a hybrid epitopes and monomers-mediated molecular-imprinted polymer enzyme-free electrochemical biosensor. MICROCHIM ACTA, 2023, 190: 118. (IF=5.7, Q1)
专利:
1) 一种用于圈党种植的装置, 2018.6.14, 中国, 201810611765.7;
2) 一种从牛蒡子中分离牛蒡子油、牛蒡苷、牛蒡苷元、牛蒡酚E和牛蒡酚H的方法, 2016.11, 中国, 201610129419.6;
3) 利用蛇足石杉细胞和内生真菌共培养富集石杉碱甲的方法, 2015.6, 中国, 201510325447.0;
4) 一种治疗烧烫伤的新型大黄素明胶微球与纳米银复合凝胶制剂, 2015.6, 中国, 201510368421.4;
5) 多功能塑料布, 2014.7, 中国, 201420373633.2;
6) 干伞器, 2014.7, 中国, 201420373609.9;
7) 一种柠檬苦素苷的提取分离技术与生产工艺, 2013.12, 中国, 201310694615.4;
8) 一种可添加在旋转蒸发仪冷凝器外的节能保护罩, 2013.12, 中国, 201320817162.5;
9) 一种治疗前列腺炎的栓剂及其制备方法, 2012.6, 中国, 201210191464.6;
10) 聚酮类化合物及其应用, 2010.6, 中国, 201010572308.5;
11) 新的呋喃类衍生物及其应用, 2010.8, 中国, 201010174476.9;
12) 新的薁类化合物及其应用, 2009.12, 中国, 200910012313.8。
团队仪器设备
拥有高效液相色谱仪、紫外可见分光光度仪、光催化装置、电化学工作站以及用于理论计算的服务器和软件等仪器设备。